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Article

Accidental selection and intentional restoration of sporulation-deficient Bacillus anthracis mutants.

Applied and environmental microbiology - 1 Sept 2010

Sastalla Inka, Rosovitz M J, Leppla Stephen H

Abstract excerpt

We demonstrate the frequent accidental enrichment of spontaneous sporulation-deficient mutants of Bacillus anthracis on solid medium and identify contributing factors. Mutations in spo0A, encoding the master regulator of sporulation initiation, were found in 38 of 53 mutants. Transductions using bacteriophage CP51 propagated on sporogenic bacteria allowed for the restoration of sporulation phenotypes.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20639373
DOI: 10.1128/AEM.00950-10
PMCID: PMC2937495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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