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Article

Germline mutations of the perforin gene are a frequent occurrence in childhood anaplastic large cell lymphoma.

Cancer - 15 Jun 2007

Cannella Sonia, Santoro Alessandra, Bruno Giuseppa, Pillon Marta, Mussolin Lara, Mangili Giovanna, Rosolen Angelo, Aricò Maurizio

Abstract excerpt

BACKGROUND: Monoallelic and biallelic mutations of the PRF1 gene have been reported in some cases of childhood lymphoma. Anaplastic large cell lymphoma (ALCL) accounts for 10% to 15% of all childhood lymphomas. To assess the possible role of PRF1 mutations in ALCL, the authors screened a series o...

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Source

Identifiers

PMID: 17477373
DOI: 10.1002/cncr.22718

Genes

PRF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17477373-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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