Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development.

Toxicology - 30 Sept 2010

Palkar Prajakta S, Anderson Cherie R, Ferry Christina H, Gonzalez Frank J, Peters Jeffrey M

Abstract excerpt

Recent work indicates that PPARalpha is required for perfluorooctanoic acid (PFOA)-induced postnatal lethality resulting from prenatal exposure. The present study tested the hypothesis that relatively modest activation of PPARalpha during prenatal development will cause postnatal lethality, similar to that observed with PFOA, a relatively low affinity PPARalpha agonist. Female wild-type and Pparalpha-null mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver
Share to Mice
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organ Size

Share to PPAR alpha

Share to Pregnancy

Share to Prenatal Exposure Delayed Effects

Share to Pyrimidines

Source

Open in PubMed Open full text

Identifiers

PMID: 20637823
DOI: 10.1016/j.tox.2010.07.008
PMCID: PMC8381260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development.PMID 20637823Read ↗

Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life.Semantic proximity Read ↗

Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American dietSemantic proximity Read ↗

Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 miceSemantic proximity Read ↗

PPAR expression and function during vertebrate developmentSemantic proximity Read ↗

Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).Semantic proximity Read ↗

Prenatal and early postnatal exposure to perfluoroalkyl substances and bone mineral content and density in the Odense Child CohortSemantic proximity Read ↗

Hepatic peroxisome proliferator-activated receptor α may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice.Semantic proximity Read ↗

Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet.Semantic proximity Read ↗

Lack of Offspring Nrf2 Does Not Exacerbate the Detrimental Metabolic Outcomes Caused by In Utero PCB126 Exposure.Semantic proximity Read ↗

Postnatal rosiglitazone administration to neonatal rat pups does not alter the young adult metabolic phenotype.Semantic proximity Read ↗

Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARα-Dependent Manner.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.