Article
Lack of Offspring Nrf2 Does Not Exacerbate the Detrimental Metabolic Outcomes Caused by In Utero PCB126 Exposure.
Frontiers in endocrinology - 1 Jan 2021
Rice Brittany B, Ngo Tenlep Sara Y, Tolaymat Obadah, Alvi Attaas T, Slone Fallon R, Crosby Claire L, Howard Stevi S, Hermanns Cecile L, Montessorie Nishimwe P, Swanson Hollie I, Pearson Kevin J
Abstract excerpt
Human environmental exposures to toxicants, such as polychlorinated biphenyls (PCBs), increase oxidative stress and disease susceptibility. Such exposures during pregnancy and/or nursing have been demonstrated to adversely affect offspring health outcomes. Nuclear factor erythroid-2-related factor 2 (Nrf2) regulates the antioxidant response and is involved in the detoxification of coplanar PCBs, like PCB126. The...
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