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Hepatic peroxisome proliferator-activated receptor α may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice.

Toxicology - 28 Oct 2011

Hayashi Yumi, Ito Yuki, Yamagishi Nozomi, Yanagiba Yukie, Tamada Hazuki, Wang Dong, Ramdhan Doni Hikmat, Naito Hisao, Harada Yukiko, Kamijima Michihiro, Gonzales Frank J, Nakajima Tamie

Abstract excerpt

Maternal exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with adverse effects on offspring, and the metabolites are agonists of peroxisome proliferator-activated receptor (PPAR) α, which exhibits species differences in expression and function. This study aimed to clarify the mechanism of DEHP-induced adverse effects on offspring in relation to maternal mouse and human PPARα. Male and female Sv/129...

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Identifiers

PMID: 21354252
DOI: 10.1016/j.tox.2011.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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