Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life.

doi:10.1016/j.mce.2009.02.021

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Article

Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life.

Molecular and cellular endocrinology - 25 May 2009

Hines Erin P, White Sally S, Stanko Jason P, Gibbs-Flournoy Eugene A, Lau Christopher, Fenton Suzanne E

Abstract excerpt

The synthetic surfactant, perfluorooctanoic acid (PFOA) is a proven developmental toxicant in mice, causing pregnancy loss, increased neonatal mortality, delayed eye opening, and abnormal mammary gland growth in animals exposed during fetal life. PFOA is found in the sera and tissues of wildlife and humans throughout the world, but is especially high in the sera of children compared to adults. These studies in...

Topics

Animals
Body Weight
Caprylates
Female
Fluorocarbons
Humans
Insulin
Leptin
Maternal Exposure
Mice
Organ Size

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovariectomy

Overweight

Phenotype

Pregnancy

Prenatal Exposure Delayed Effects

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PMID: 19433254
DOI: 10.1016/j.mce.2009.02.021

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