Article
Postnatal rosiglitazone administration to neonatal rat pups does not alter the young adult metabolic phenotype.
Neonatology - 1 Jan 2012
Truong Nghia C, Abbasi Afshan, Sakurai Reiko, Lee W N Paul, Torday John S, Rehan Virender K
Abstract excerpt
BACKGROUND: Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-γ (PPARγ) agonist, significantly enhances lung maturation without affecting blood biochemical and metabolic profiles in the newborn period. However, whether this exposure to RGZ in neonatal life alters the adult metabolic phenotype is not known. OBJECTIVE: To determine the effects of early postnatal administration of RGZ on the young...
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