Article
Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression.
Bipolar disorders - 1 Jun 2010
Quinn Emma M, Hill Matthew, Anney Richard, Gill Michael, Corvin Aiden P, Morris Derek W
Abstract excerpt
OBJECTIVES: Genome-wide association studies (GWAS) have identified Ankyrin-G (ANK3) and the alpha-1C subunit of the L-type voltage-gated calcium channel (CACNA1C) as susceptibility genes for bipolar disorder. Available biological information on these genes suggests a potential molecular mechanism involving ion channel dysfunction. The associated single nucleotide polymorphisms (SNPs) at ANK3 (rs10994336) and...
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