Article
Promoter polymorphisms and allelic imbalance in ABCB1 expression.
Pharmacogenetics and genomics - 1 Nov 2007
Loeuillet Corinne, Weale Michael, Deutsch Samuel, Rotger Margalida, Soranzo Nicole, Wyniger Josiane, Lettre Guillaume, Dupré Yann, Thuillard Delphine, Beckmann Jacques S, Antonarakis Stylianos E, Goldstein David B, Telenti Amalio
Abstract excerpt
OBJECTIVE: The ABCB1 (MDR1) gene, encoding the transporter P-glycoprotein, is known to act on a broad range of prescription medicines. For this reason a large number of studies have assessed the functional consequences of variation in this gene. Particular attention has focused on the ABCB1_3435C...
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