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In silico characterisation of the two-component system regulators of Streptococcus pyogenes.

PloS one - 1 Jan 2018

Buckley Sean J, Timms Peter, Davies Mark R, McMillan David J

Abstract excerpt

Bacteria respond to environmental changes through the co-ordinated regulation of gene expression, often mediated by two-component regulatory systems (TCS). Group A Streptococcus (GAS), a bacterium which infects multiple human body sites and causes multiple diseases, possesses up to 14 TCS. In this study we examined genetic variation in the coding sequences and non-coding DNA upstream of these TCS as a method for...

Topics

Alleles
Computer Simulation
DNA, Intergenic
Gene Expression Regulation, Bacterial
Genome, Bacterial
Regulatory Sequences, Nucleic Acid
Streptococcus pyogenes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29927994
DOI: 10.1371/journal.pone.0199163
PMCID: PMC6013163

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