Article
Parent-of-origin effect in multiple sclerosis: observations in half-siblings.
Lancet (London, England) - 29 May 2004
Ebers G C, Sadovnick A D, Dyment D A, Yee I M L, Willer C J, Risch Neil
Abstract excerpt
Multiple sclerosis is a complex trait in which occurrence rates in offspring are 20-50-fold greater than in the general population. Parent-of-origin effects have been difficult to screen for, since most cases are sporadic. We have compared recurrence risks in half-siblings with respect to their parent in common. Of the 1567 index cases with half-siblings in multiple sclerosis clinics across Canada, we recorded...
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