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Article

Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.

Journal of virology - 1 Oct 2010

Taddeo Brunella, Zhang Weiran, Roizman Bernard

Abstract excerpt

The virion host shutoff (VHS) RNase tegument protein released into cells by infecting virus has two effects. Preexisting stable mRNAs (e.g., GAPDH [glyceraldehyde-3-phosphate dehydrogenase]) are rapidly degraded. Stress response RNAs containing AU-rich elements (AREs) in the 3' untranslated region (3'UTR) are deadenylated and cleaved, but the cleavage products persist for hours, in contrast to the short...

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Identifiers

PMID: 20631134
DOI: 10.1128/JVI.00975-10
PMCID: PMC2937800

Genes

GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.PMID 20631134Read ↗

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