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Article

Rescue of defective MC4R cell-surface expression and signaling by a novel pharmacoperone Ipsen 17.

Journal of molecular endocrinology - 1 Aug 2014

Wang Xiao-Hua, Wang Hao-Meng, Zhao Bao-Lei, Yu Peng, Fan Zhen-Chuan

Abstract excerpt

Melanocortin 4 receptor (MC4R) is a key factor in regulating energy homeostasis, and null mutations occurring in the gene encoding MC4R cause severe early-onset morbid obesity in humans. Many obesity-causing mutations affecting MC4R clinically identified so far lead to failure of mutant receptors...

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Source

Identifiers

PMID: 24780838
DOI: 10.1530/JME-14-0005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24780838-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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