Article
The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2011
Meimaridou Eirini, Gooljar Sakina B, Ramnarace Nalini, Anthonypillai Lucia, Clark Adrian J L, Chapple J Paul
Abstract excerpt
Inherited modifications in protein structure frequently cause a loss-of-function by interfering with protein synthesis, transport, or stability. For the obesity-linked melanocortin-4 receptor (MC4R) and other G protein-coupled receptors, many mutants are intracellular retained. The biogenesis and trafficking of G protein-coupled receptors are regulated by multiple factors, including molecular chaperone networks....
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