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Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line.

Immunology and cell biology - 1 Feb 2011

Otani Takeshi, Tsuji-Takayama Kazue, Okochi Ayumi, Yamamoto Mayuko, Takeuchi Makoto, Yamasaki Fumiyuki, Nakamura Shuji, Kibata Masayoshi

Abstract excerpt

We have previously shown that xenogeneic stromal cell stimulation of naïve T cells resulted in the generation of a new type of regulatory T (Treg) cell termed HOZOT, which has multifunctional properties and a CD4/CD8 double-positive phenotype. Even after the establishment of HOZOT, stromal cells can function as an antigen-presenting cell (APC) by inducing these cells to produce interleukin (IL)-10. When compared...

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PMID: 20628373
DOI: 10.1038/icb.2010.87

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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