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Article

Beta1-adrenoceptor polymorphism predicts flecainide action in patients with atrial fibrillation.

PloS one - 2 Jul 2010

Nia Amir M, Caglayan Evren, Gassanov Natig, Zimmermann Tom, Aslan Orhan, Hellmich Martin, Duru Firat, Erdmann Erland, Rosenkranz Stephan, Er Fikret

Abstract excerpt

BACKGROUND: Antiarrhythmic action of flecainide is based on sodium channel blockade. Beta(1)-adrenoceptor (beta(1)AR) activation induces sodium channel inhibition, too. The aim of the present study was to evaluate the impact of different beta(1)AR genotypes on antiarrhythmic action of flecainide in patients with structural heart disease and atrial fibrillation. METHODOLOGY/PRINCIPAL FINDINGS: In 145 subjects, 87...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 20625396
DOI: 10.1371/journal.pone.0011421
PMCID: PMC2896398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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