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Article

Type and location of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia.

Leukemia & lymphoma - 1 May 2013

Koszarska Magdalena, Bors Andras, Feczko Angela, Meggyesi Nora, Batai Arpad, Csomor Judit, Adam Emma, Kozma Andras, Orban Tamas I, Lovas Nora, Sipos Andrea, Karaszi Eva, Dolgos Janos, Fekete Sandor, Reichardt Judit, Lehoczky Eniko, Masszi Tamas, Tordai Attila, Andrikovics Hajnalka

Abstract excerpt

Mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) are genetic alterations in acute myeloid leukemia (AML). The aim of our study was to investigate the frequency and prognostic effect of IDH1/2 mutations together followed by an individual analysis of each substitution in a Hungarian cohort consisting of 376 patients with AML. IDH1(mut) and IDH2(mut) were mutually exclusive, detected in 8.5% and 7.5% of cases,...

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Source

Identifiers

PMID: 23039322
DOI: 10.3109/10428194.2012.736981

Genes

IDH1
IDH2
NPM1
ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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