Article
Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.
Scientific reports - 18 Jun 2018
Philp Amber R, Riquelme Texia T, Millar-Büchner Pamela, González Rodrigo, Sepúlveda Francisco V, Cid L Pablo, Flores Carlos A
Abstract excerpt
Nearly 70% of cystic fibrosis (CF) patients bear the phenylalanine-508 deletion but disease severity differs greatly, and is not explained by the existence of different mutations in compound heterozygous. Studies demonstrated that genes other than CFTR relate to intestinal disease in humans and CF-mouse. Kcnn4, the gene encoding the calcium-activated potassium channel KCa3.1, important for intestinal secretion,...
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