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Article

Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.

Addiction biology - 1 Jul 2010

Grucza Richard A, Johnson Eric O, Krueger Robert F, Breslau Naomi, Saccone Nancy L, Chen Li-Shiun, Derringer Jaime, Agrawal Arpana, Lynskey Michael, Bierut Laura J

Abstract excerpt

Nicotine dependence is moderately heritable, but identified genetic associations explain only modest portions of this heritability. We analyzed 3369 SNPs from 349 candidate genes and investigated whether incorporation of SNP-by-environment interaction into association analyses might bolster gene discovery efforts and prediction of nicotine dependence. Specifically, we incorporated the interaction between allele...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, N-Methyl-D-Aspartate

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Source

Open in PubMed Open full text

Identifiers

PMID: 20624154
DOI: 10.1111/j.1369-1600.2010.00220.x
PMCID: PMC3085318

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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