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Article

A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes.

BMC genetics - 1 Jul 2014

Li Ming, Gardiner Joseph C, Breslau Naomi, Anthony James C, Lu Qing

Abstract excerpt

BACKGROUND: Cox-regression-based methods have been commonly used for the analyses of survival outcomes, such as age-at-disease-onset. These methods generally assume the hazard functions are proportional among various risk groups. However, such an assumption may not be valid in genetic association studies, especially when complex interactions are involved. In addition, genetic association studies commonly adopt...

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Source

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Identifiers

PMID: 24986733
DOI: 10.1186/1471-2156-15-79
PMCID: PMC4087128

Genes

CSMD1
GRIK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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