Article
Eight-plex iTRAQ analysis of variant metastatic human prostate cancer cells identifies candidate biomarkers of progression: An exploratory study.
The Prostate - 1 Sept 2010
Glen Adam, Evans Caroline A, Gan Chee S, Cross Simon S, Hamdy Freddie C, Gibbins Jonathan, Lippitt Jenny, Eaton Colby L, Noirel Josselin, Wright Phillip C, Rehman Ishtiaq
Abstract excerpt
BACKGROUND: Due to the heterogeneity in the biological behavior of prostate cancer, biomarkers that can reliably distinguish indolent from aggressive disease are urgently needed to inform treatment choices. METHODS: We employed 8-plex isobaric Tags for Relative and Absolute Quantitation (iTRAQ), to profile the proteomes of two distinct panels of isogenic prostate cancer cells with varying growth and metastatic...
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