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Article

Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance

22 Nov 2019

Abstract excerpt

The exact biological mechanism governing the radioresistant phenotype of prostate tumours at a high risk of recurrence despite the delivery of advanced radiotherapy protocols remains unclear. This study analysed the protein expression profiles of a previously generated isogenic 22Rv1 prostate cancer model of radioresistance using DigiWest multiplex protein profiling for a selection of 90 signalling proteins....

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PMID: 31758038
DOI: 10.1038/s41598-019-53799-7

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