Article
A novel prostate cancer subtyping classifier based on luminal and basal phenotypes.
Cancer - 15 Jul 2023
Weiner Adam B, Liu Yang, Hakansson Alex, Zhao Xin, Proudfoot James A, Ho Julian, Zhang Jj H, Li Eric V, Karnes R Jeffrey, Den Robert B, Kishan Amar U, Reiter Robert E, Hamid Anis A, Ross Ashely E, Tran Phuoc T, Davicioni Elai, Spratt Daniel E, Attard Gerhardt, Lotan Tamara L, Lee Kiang Chua Melvin, Sweeney Christopher J, Schaeffer Edward M
Abstract excerpt
BACKGROUND: Prostate cancer (PCa) is a clinically heterogeneous disease. The creation of an expression-based subtyping model based on prostate-specific biological processes was sought. METHODS: Unsupervised machine learning of gene expression profiles from prospectively collected primary prostate tumors (training, n = 32,000; evaluation, n = 68,547) was used to create a prostate subtyping classifier (PSC) based...
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