Article
Genotype-controlled analysis of serum dopamine β-hydroxylase activity in civilian post-traumatic stress disorder.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Dec 2010
Tang Yi-lang, Li Wenbiao, Mercer Kristina, Bradley Bekh, Gillespie Charles F, Bonsall Robert, Ressler Kerry J, Cubells Joseph F
Abstract excerpt
BACKGROUND: Norepinephrine (NE) plays a central role in post-traumatic stress disorder (PTSD). Dopamine β-hydroxylase (DβH) converts dopamine (DA) to NE and its activity varies widely across individuals. Mustapic et al. (2007) reported a PTSD-associated deficit in serum DβH activity in a genotype-controlled analysis of combat veterans. We tested whether such a deficit would occur in a sample of civilians....
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