Sex dependent influence of a functional polymorphism in steroid 5-α-reductase type 2 (SRD5A2) on post-traumatic stress symptoms.

doi:10.1002/ajmg.b.32147

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Article

Sex dependent influence of a functional polymorphism in steroid 5-α-reductase type 2 (SRD5A2) on post-traumatic stress symptoms.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2013

Gillespie Charles F, Almli Lynn M, Smith Alicia K, Bradley Bekh, Kerley Kimberly, Crain Daniel F, Mercer Kristina B, Weiss Tamara, Phifer Justine, Tang Yilang, Cubells Joseph F, Binder Elisabeth B, Conneely Karen N, Ressler Kerry J

Abstract excerpt

A non-synonymous, single nucleotide polymorphism (SNP) in the gene coding for steroid 5-α-reductase type 2 (SRD5A2) is associated with reduced conversion of testosterone to dihydrotestosterone (DHT). Because SRD5A2 participates in the regulation of testosterone and cortisol metabolism, hormones shown to be dysregulated in patients with PTSD, we examined whether the V89L variant (rs523349) influences risk for...

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PMID: 23505265
DOI: 10.1002/ajmg.b.32147
PMCID: PMC3770127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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