Article
Analysis of innate defences against Plasmodium falciparum in immunodeficient mice.
Malaria journal - 9 Jul 2010
Arnold Ludovic, Tyagi Rajeev Kumar, Mejia Pedro, Van Rooijen Nico, Pérignon Jean-Louis, Druilhe Pierre
Abstract excerpt
BACKGROUND: Mice with genetic deficiencies in adaptive immunity are used for the grafting of human cells or pathogens, to study human diseases, however, the innate immune responses to xenografts in these mice has received little attention. Using the NOD/SCID Plasmodium falciparum mouse model an analysis of innate defences responsible for the substantial control of P. falciparum which remains in such mice, was...
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