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Human Malaria in Immunocompromised Mice

4 Dec 2000

Abstract excerpt

We have recently described that sustained Plasmodium falciparum growth could be obtained in immunodeficient mice. We now report the potential of this new mouse model by assaying the effect of the passive transfer of antibodies (Abs) which in humans have had a well-established effect.Our results show that the total African adult hyperimmune immunoglobulin Gs (HI-IgGs) strongly reduce P. falciparum parasitemia...

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PMID: 11104807
DOI: 10.1084/jem.192.11.1653

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