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Article

Breast cancer: a candidate gene approach across the estrogen metabolic pathway.

Breast cancer research and treatment - 1 Mar 2008

Justenhoven Christina, Hamann Ute, Schubert Falk, Zapatka Marc, Pierl Christiane B, Rabstein Sylvia, Selinski Silvia, Mueller Tina, Ickstadt Katja, Gilbert Michael, Ko Yon-Dschun, Baisch Christian, Pesch Beate, Harth Volker, Bolt Hermann M, Vollmert Caren, Illig Thomas, Eils Roland, Dippon Jürgen, Brauch Hiltrud

Abstract excerpt

Polymorphisms within the estrogen metabolic pathway are prime candidates for a possible association with breast cancer risk. We investigated 11 genes encoding key proteins of this pathway for their potential contribution to breast cancer risk. Of these CYP17A1, CYP19A1, EPHX1, HSD17B1, SRD5A2, and PPARG2 participate in biosynthesis, CYP1A1, CYP1B1, COMT, GSTP1, and SOD2 in catabolism and detoxification. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 17588204
DOI: 10.1007/s10549-007-9586-8

Genes

COMT
EPHX1
GSTP1
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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