Article
Mechanical Overloading Increases Maximal Force and Reduces Fragility in Hind Limb Skeletal Muscle from Mdx Mouse.
The American journal of pathology - 1 Jul 2015
Ferry Arnaud, Parlakian Ara, Joanne Pierre, Fraysse Bodvael, Mgrditchian Takouhie, Roy Pauline, Furling Denis, Butler-Browne Gillian, Agbulut Onnik
Abstract excerpt
There is fear that mechanical overloading (OVL; ie, high-force contractions) accelerates Duchenne muscular dystrophy. Herein, we determined whether short-term OVL combined with wheel running, short-term OVL combined with irradiation, and long-term OVL are detrimental for hind limb mdx mouse muscle, a murine model of Duchene muscular dystrophy exhibiting milder dystrophic features. OVL was induced by the surgical...
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