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Article

Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese.

Drug metabolism and pharmacokinetics - 1 Jan 2010

Ariyoshi Noritaka, Iga Yukako, Hirata Koji, Sato Yasunori, Miura Go, Ishii Itsuko, Nagamori Seiji, Kitada Mitsukazu

Abstract excerpt

Hepatotoxicity is the most frequent adverse drug reaction (ADR) in Japanese treated with ticlopidine (TP). We investigated the relationship between CYP2B6 haplotype and incidence of TP-induced hepatotoxicity in 114 Japanese patients. Although 4 haplotypes (*1A, *1H, *1J and *6B) accounted for more than 80% of the inferred haplotypes in both control (n=81) and case (n=22) subjects, the prevalence was apparently...

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Identifiers

PMID: 20610889
DOI: 10.2133/dmpk.25.298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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