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Article

NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Feb 2014

Piper Michael, Barry Guy, Harvey Tracey J, McLeay Robert, Smith Aaron G, Harris Lachlan, Mason Sharon, Stringer Brett W, Day Bryan W, Wray Naomi R, Gronostajski Richard M, Bailey Timothy L, Boyd Andrew W, Richards Linda J

Abstract excerpt

Epigenetic mechanisms are essential in regulating neural progenitor cell self-renewal, with the chromatin-modifying protein Enhancer of zeste homolog 2 (EZH2) emerging as a central player in promoting progenitor cell self-renewal during cortical development. Despite this, how Ezh2 is itself regulated remains unclear. Here, we demonstrate that the transcription factor nuclear factor IB (NFIB) plays a key role in...

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Identifiers

PMID: 24553933
DOI: 10.1523/JNEUROSCI.2319-13.2014
PMCID: PMC3931505

Genes

NFIB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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