Article

Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells

2020-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Posttranslational modifications (PTMs) on histone tails spatiotemporally dictate mammalian neural stem cell (NSC) fate. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor β (TGF-β) superfamily, suppresses NSC proliferation and fosters differentiation into astroglial cells. Whether PTMs mediate these effects of BMP4 is unknown. Here we demonstrate that BMP4 signaling...

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Literature Corpus work: e43f4394-c343-5dbf-aa27-96adad279e6a
DOI: 10.1101/2020.01.22.915934

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