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Article

Chloride intracellular channel 4 is critical for the epithelial morphogenesis of RPE cells and retinal attachment.

Molecular biology of the cell - 1 Sept 2010

Chuang Jen-Zen, Chou Szu-Yi, Sung Ching-Hwa

Abstract excerpt

Retinal detachment is a sight-threatening condition. The molecular mechanism underlying the adhesion between the RPE and photoreceptors is poorly understood because the intimate interactions between these two cell types are impossible to model and study in vitro. In this article, we show that chloride intracellular channel 4 (CLIC4) is enriched at apical RPE microvilli, which are interdigitated with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20610659
DOI: 10.1091/mbc.E09-10-0907
PMCID: PMC2929995

Genes

RPE
CLIC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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