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Article

p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells.

The Prostate - 1 Jan 2011

Tsui Ke-Hung, Feng Tsui-Hsia, Lin Yu-Fen, Chang Phei-Lang, Juang Horng-Heng

Abstract excerpt

BACKGROUND: Mitochondrial aconitase (mACON) is regarded as the key enzyme in citrate oxidation in human prostate epithelial cells, and its abnormal expression has been implicated in tumorigenesis of the prostate. Evidence also supports a broad role for the p53 gene in suppressing prostatic tumorigenesis. We investigated whether p53 regulates mACON expression and explore the potential mechanisms responsible for...

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Identifiers

PMID: 20607720
DOI: 10.1002/pros.21222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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