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Article

ALS‐associated fused in sarcoma (FUS) mutations disrupt Transportin‐mediated nuclear import

6 Jul 2010

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 20606625
DOI: 10.1038/emboj.2010.143

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Related research

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ALS‐associated fused in sarcoma (FUS) mutations disrupt Transportin‐mediated nuclear importPMID 20606625Read ↗

Autosomal dominant inheritance of rapidly progressive amyotrophic lateral sclerosis due to a truncation mutation in the fused in sarcoma (FUS) gene.Semantic proximity Read ↗

FUS-NLS/Transportin 1 Complex Structure Provides Insights into the Nuclear Targeting Mechanism of FUS and the Implications in ALSSemantic proximity Read ↗

Importance of Functional Loss of FUS in FTLD/ALSSemantic proximity Read ↗

Transportin 1 accumulates in FUS inclusions in adult-onset ALS without FUS mutation.Semantic proximity Read ↗

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.Semantic proximity Read ↗

Transportin1: a marker of FTLD-FUSSemantic proximity Read ↗

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALSSemantic proximity Read ↗

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.Semantic proximity Read ↗

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.Semantic proximity Read ↗

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granulesSemantic proximity Read ↗

Amyotrophic Lateral Sclerosis, FUS and Protein Synthesis Defects.Semantic proximity Read ↗

Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.Semantic proximity Read ↗

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