Article
Paradigm of genetic mosaicism and lone atrial fibrillation: physiological characterization of a connexin 43-deletion mutant identified from atrial tissue.
Circulation - 20 Jul 2010
Thibodeau Isabelle L, Xu Ji, Li Qiuju, Liu Gele, Lam Khanh, Veinot John P, Birnie David H, Jones Douglas L, Krahn Andrew D, Lemery Robert, Nicholson Bruce J, Gollob Michael H
Abstract excerpt
BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia observed in otherwise healthy individuals. Most lone AF cases are nonfamilial, leading to the assumption that a primary genetic origin is unlikely. In this study, we provide data supporting a novel paradigm that atrial tissue-specific genetic defects may be associated with sporadic cases of lone AF. METHODS AND RESULTS: We sequenced the...
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