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Article

Atrial fibrillation-linked GJA5/connexin40 mutants impaired gap junctions via different mechanisms.

FEBS letters - 17 Apr 2014

Bai Donglin

Abstract excerpt

The gap junctions (GJs) formed by Cx40 and Cx43 provide a low resistance passage allowing for rapid propagation of action potentials. Sporadic somatic mutations in GJA5 (encoding Cx40) have been identified in lone atrial fibrillation (AF) patients. More recently germline autosomal dominantly inherited mutations in GJA5 have been found in early onset lone AF patients in several families over generations....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24656738
DOI: 10.1016/j.febslet.2014.02.064

Genes

GJA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Atrial fibrillation-linked GJA5/connexin40 mutants impaired gap junctions via different mechanisms.PMID 24656738Read ↗

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Functional Characterization of Novel Atrial Fibrillation-Linked GJA5 (Cx40) Mutants.Semantic proximity Read ↗

An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels.Semantic proximity Read ↗

The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice.Semantic proximity Read ↗

Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function.Semantic proximity Read ↗

Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties.Semantic proximity Read ↗

Somatic Mutations in the Connexin 40 Gene ( <i>GJA5</i> ) in Atrial FibrillationSemantic proximity Read ↗

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