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Article

Enhanced antimicrobial activity of engineered human lysozyme.

ACS chemical biology - 17 Sept 2010

Scanlon Thomas C, Teneback Charlotte C, Gill Avinash, Bement Jenna L, Weiner Joshua A, Lamppa John W, Leclair Laurie W, Griswold Karl E

Abstract excerpt

Lysozymes contain a disproportionately large fraction of cationic residues, and are thereby attracted toward the negatively charged surface of bacterial targets. Importantly, this conserved biophysical property may inhibit lysozyme antibacterial function during acute and chronic infections. A mouse model of acute pulmonary Pseudomonas aeruginosa infection demonstrated that anionic biopolymers accumulate to high...

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PMID: 20604527
DOI: 10.1021/cb1001119
PMCID: PMC2942966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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