PL3 Amidase, a Tailor-made Lysin Constructed by Domain Shuffling with Potent Killing Activity against Pneumococci and Related Species

Abstract excerpt

The emergence and spread of antibiotic-resistant bacteria is pushing the need of alternative treatments. In this context, phage therapy is already a reality to successfully fight certain multiresistant bacteria. Among different phage gene products, murein hydrolases responsible of phage progeny liberation (also called lysins or endolysins) are weapons that target specific peptidoglycan bonds, leading to lysis and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Peptides and Activities
• Share to Pneumocystis jirovecii pneumonia detection and treatment
• Share to Pneumonia and Respiratory Infections