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Article

Herpes simplex virus‐1 induces expression of a novel MxA isoform that enhances viral replication

6 Jul 2010

Abstract excerpt

MxA is an antiviral protein induced by interferon (IFN)-α/β that is known to inhibit the replication of many RNA viruses. In these experiments, the 76-kDa MxA protein expressed in IFN-α-treated cells was shown to have antiviral activity against herpes simplex virus-1 (HSV-1), a human DNA virus. However, MxA was expressed as a 56-kDa protein in HSV-1-infected cells in the absence of IFN-α. This previously...

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PMID: 20603636
DOI: 10.1038/icb.2010.83

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