Article
Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.
Nature communications - 21 Nov 2017
Huang Chang, Yang Fu, Zhang Zhuqiang, Zhang Jing, Cai Gaihong, Li Lin, Zheng Yong, Chen She, Xi Rongwen, Zhu Bing
Abstract excerpt
Ash1 is a Trithorax group protein that possesses H3K36-specific histone methyltransferase activity, which antagonizes Polycomb silencing. Here we report the identification of two Ash1 complex subunits, Mrg15 and Nurf55. In vitro, Mrg15 stimulates the enzymatic activity of Ash1. In vivo, Mrg15 is recruited by Ash1 to their common targets, and Mrg15 reinforces Ash1 chromatin association and facilitates the proper...
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