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Article

Mass spectrometric approach for characterizing the disordered tail regions of the histone H2A/H2B dimer.

Analytical chemistry - 17 Feb 2015

Saikusa Kazumi, Nagadoi Aritaka, Hara Kana, Fuchigami Sotaro, Kurumizaka Hitoshi, Nishimura Yoshifumi, Akashi Satoko

Abstract excerpt

The histone H2A/H2B dimer is a component of nucleosome core particles (NCPs). The structure of the dimer at the atomic level has not yet been revealed. A possible reason for this is that the dimer has three intrinsically disordered tail regions: the N- and C-termini of H2A and the N-terminus of H2B. To investigate the role of the tail regions of the H2A/H2B dimer structure, we characterized behaviors of the...

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PMID: 25594579
DOI: 10.1021/ac503689w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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