Article
Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects.
Biochemical and biophysical research communications - 30 Jul 2010
Yamazaki Yuji, Imura Akihiro, Urakawa Itaru, Shimada Takashi, Murakami Junko, Aono Yukiko, Hasegawa Hisashi, Yamashita Takeyoshi, Nakatani Kimihiko, Saito Yoshihiko, Okamoto Nozomi, Kurumatani Norio, Namba Noriyuki, Kitaoka Taichi, Ozono Keiichi, Sakai Tomoyuki, Hataya Hiroshi, Ichikawa Shoji, Imel Erik A, Econs Michael J, Nabeshima Yo-Ichi
Abstract excerpt
BACKGROUND: Alpha-Klotho (alphaKl) regulates mineral metabolism such as calcium ion (Ca(2+)) and inorganic phosphate (Pi) in circulation. Defects in mice result in clinical features resembling disorders found in human aging. Although the importance of transmembrane-type alphaKl has been demonstra...
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