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Article

The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

15 Apr 2014

Abstract excerpt

BACKGROUND: Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in genes in this pathway (IL4, IL4R, IL13, GATA3, and STAT6) influence asthma risk, that such influences are age-dependent, and that methylation of some CpG sites changes over time in accordance...

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PMID: 24735657
DOI: 10.1186/1868-7083-6-8

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