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Article

Characteristic promoter hypermethylation signatures in male germ cell tumors.

1 Jan 2002

Abstract excerpt

BACKGROUND: Human male germ cell tumors (GCTs) arise from undifferentiated primordial germ cells (PGCs), a stage in which extensive methylation reprogramming occurs. GCTs exhibit pluripotentiality and are highly sensitive to cisplatin therapy. The molecular basis of germ cell (GC) transformation, differentiation, and exquisite treatment response is poorly understood. RESULTS: To assess the role and mechanism of...

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Share to Epigenetics and DNA Methylation
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PMID: 12495446
DOI: 10.1186/1476-4598-1-8

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