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Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights

7 Jan 2022

Abstract excerpt

BACKGROUND: Type II germ cell tumors (GCT) are the most common solid cancers in males of age 15 to 35 years. Treatment of these tumors includes cisplatin-based therapy achieving high cure rates, but also leading to late toxicities. As mainly young men are suffering from GCTs, late toxicities play a major role regarding life expectancy, and the development of therapy resistance emphasizes the need for alternative...

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PMID: 34996497
DOI: 10.1186/s13148-021-01223-1

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