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Article

Reactivation of mutant p53 by capsaicin, the major constituent of peppers.

Journal of experimental & clinical cancer research : CR - 6 Sept 2016

Garufi Alessia, Pistritto Giuseppa, Cirone Mara, D'Orazi Gabriella

Abstract excerpt

BACKGROUND: Mutations in the p53 oncosuppressor gene are highly frequent in human cancers. These alterations are mainly point mutations in the DNA binding domain of p53 and disable p53 from transactivating target genes devoted to anticancer activity. Mutant p53 proteins are usually more stable than wild-type p53 and may not only impair wild-type p53 activity but also acquire pro-oncogenic functions. Therefore,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27599722
DOI: 10.1186/s13046-016-0417-9
PMCID: PMC5012067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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