Article
Reactivation of mutant p53: a new strategy for cancer therapy.
Seminars in cancer biology - 1 Jan 1998
Selivanova G, Kawasaki T, Ryabchenko L, Wiman K G
Abstract excerpt
The specific DNA binding activity of p53 is crucial for its tumor suppression function. Naturally occurring mutant forms of p53 are deficient for specific DNA binding. However, several studies have indicated that their specific DNA binding can be reactivated. Short peptides derived from the p53 C...
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