Article
Role of glucocorticoid receptor polymorphism in adrenal incidentalomas.
European journal of clinical investigation - 1 Sept 2010
Morelli Valentina, Donadio Francesca, Eller-Vainicher Cristina, Cirello Valentina, Olgiati Luca, Savoca Chiara, Cairoli Elisa, Salcuni Antonio Stefano, Beck-Peccoz Paolo, Chiodini Iacopo
Abstract excerpt
BACKGROUND: Adrenal incidentalomas (AI) have been associated with and an increased prevalence of metabolic and bone complications. The N363S and BclI polymorphisms of the glucocorticoid receptor (GR) have been associated with an increased sensitivity to glucocorticoid (GC). This observational study aims to evaluate whether BclI and N363S polymorphisms play a role in the development of complications in AI....
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