Article
Glucocorticoid receptor and molecular chaperones in the pathogenesis of adrenal incidentalomas: potential role of reduced sensitivity to glucocorticoids.
Molecular medicine (Cambridge, Mass.) - 22 Jan 2013
Damjanovic Svetozar S, Antic Jadranka A, Ilic Bojana B, Cokic Bojana Beleslin, Ivovic Miomira, Ognjanovic Sanja I, Isailovic Tatjana V, Popovic Bojana M, Bozic Ivana B, Tatic Svetislav, Matic Gordana, Todorovic Vera N, Paunovic Ivan
Abstract excerpt
Glucocorticoid (GC) sensitivity depends on glucocorticoid receptor (GR) and heat shock proteins (Hsps). We investigated whether common GR genes (ER22/23EK, N363S, Bcl I, and 9β) and adrenocorticotropin receptor promoter polymorphisms influence susceptibility for unilateral adrenal incidentaloma (AI), plus GR and Hsp expression in tumorous (n = 19), peritumorous (n = 13) and normal adrenocortical (n = 11) tissues....
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